Rios connected in the fifth, hitting a two-out drive to left on an 0-2 pitch from Zach McAllister. Rios’ team-high sixth homer made it 3-0.
McAllister (1-3) walked five and allowed five hits in 5 2-3 innings. Four relievers then combined for 2 1-3 innings of hitless ball, giving the Indians a chance to rally.
Cleveland’s first three batters of the sixth got on base, with Jason Kipnis singling in Drew Stubbs. Nate Jones then replaced Quintana and Mark Reynolds hit a sacrifice fly to cut Chicago’s lead to 3-2.
Kipnis stole second and third, but Jones struck out Nick Swisher and got Ryan Raburn to fly out to end the inning.
The Indians rallied for a 3-2 victory in the series opener on Monday night. Tuesday game’s was postponed by rain and has not been rescheduled.
Chicago got off to a nice start when Alejandro De Aza had a leadoff walk in the first. He stole second and came home on Keppinger’s single to center.
The White Sox threatened again in the third, putting runners on first and second with one out. But Keppinger popped out and Rios grounded out to end the inning.
Quintana breezed through three perfect innings, and then worked out of a jam in the fourth after the Indians loaded the bases.
Brantley reached on a leadoff single and moved to third on Reynolds’ one-out double to the right-field corner. Ryan Raburn walked to load the bases, but Mike Aviles grounded into an inning-ending double play.
White Sox slugger Adam Dunn walked three times. He was 0 for 1 on the day and is 2 for 46 (.043) in his last 11 games.
Chicago opens a four-game series with visiting Tampa Bay on Thursday while Cleveland is off. The Indians begin a four-game set Friday at Kansas City.
NOTES: The Indians activated C Lou Marson (neck strain) from the 15-day disabled list and optioned Yan Gomes to Class AAA Columbus. Marson got the start and went 0 for 3. C Yan Gomes was sent to Class AAA Columbus. “He needs to play, for his career this is a good thing for him to do right now,” Indians manager Terry Francona said. ... Indians OF Michael Bourn is scheduled to be examined Thursday in Cleveland and could resume baseball activities with the removal of sutures from a right index finger laceration. He’s scheduled to come off the disabled list on April 30.