Joe Flacco completed 12 of 23 passes for 282 yards and two scores as the Ravens ended the Colts' season with a superior second half.
The Colts' offense, playing without coordinator Bruce Arians, who was hospitalized before the game, managed only three Adam Vinatieri field goals.
Colts quarterback Andrew Luck completed 28 of 54 passes for 288 yards and one interception. Reggie Wayne caught nine passes for 114 yards and moved into second place in career playoff receptions behind Jerry Rice.
The Ravens took a 17-6 lead on a Flacco to Dennis Pitta 20-yard touchdown pass in the third quarter, set up by a 46-yard Flacco completion to Anquan Boldin, who set a team playoff record with 145 yards receiving. The Colts cut it to 17-9 with a near-eight minute drive and a Vinatieri field goal with 40 seconds left in the third.
Indy had a chance to cut it down further, but a drop by Donnie Avery stalled the drive at the Ravens' 22 and Vinatieri missed wide right on a 40-yard field goal attempt.
Baltimore made the Colts pay for those miscues, pushing the lead to 24-9 on a big Bernard Pierce run and a Flacco touchdown pass to Boldin with 9:14 left.
The margin was too much for the Colts to overcome, as a late drive that could have closed the gap ended with a Luck pass being intercepted by Cary Williams.
The Colts encountered unexpected adversity early Sunday Arians was admitted to a local hospital with an unspecified illness. He had missed time this week because of illness, too.
Arians was expected to remain in the hospital overnight. In his absence, quarterbacks coach Clyde Christensen assumed the offensive coordinator duties. Christensen served as Colts offensive coordinator for two seasons under Jim Caldwell.
Arians, of course, was the Colts' interim head coach for 12 games while coach Chuck Pagano was fighting leukemia.
The Colts' offense had one drive thwarted in the first half when Luck was sacked and fumbled, but managed two field goals, including a 52-yard as the half expired to cut Baltimore's lead to 10-6. That score, on a drive that started with 50 seconds left, was set up by a big 25-yard completion to T.Y. Hilton on 3rd-and-26. Coby Fleener threw a nice block on the play.
Baltimore's biggest first-half play was a screen pass from Flacco to Ray Rice for 47 yards, setting up a Vonta Leach score for the only first-half touchdown that put the Ravens up 10-3.